Pmid Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover.
TP53 transactivates siah-1 leading to ubiquitin-mediated proteasome degradation of oncogenic (unphosphorylated) b -catenin.
4 Early B cell development: from stem cell to immature B cell B cells undergo two types of selection while developing in the bone marrow to ensure proper development.
Interestingly, plakoglobin, also called g -catenin, shares overall 70 amino acid identity with b -catenin and as much as 80 within the arm repeat domain (Huber and Weis, 2001).Pmid 1303292 APC binds to the novel protein EB1.Recommended articles, citing articles (0 crown copyright 2013 Published by Elsevier Inc).1994 ; 8 (1) : 118-130.Pmid active sms lock v 1.10 beta 9096311 clinical pediatric neurology pdf pten/mmac1 mutations in endometrial cancers.Mao B, Wu W, Davidson G, Marhold J, Li M, Mechler BM, Delius H, Hoppe D, Stannek P, Walter C, Glinka A, Niehrs C Nature.
Three human homologues are identified, sarp1-3, but they show distinct expression pattern (Melkonyan., 1997).
1997 ; 57 (21).
1991 ; 64 (2) : page 231.APC Patients with familial adenomatous polyposis coli (FAP) harbor a germline mutation in the tumor suppressor gene APC.Li X, Yost HJ, Virshup DM, Seeling JM The embo journal.Journal international du cancer.1998 ; 216 (1) : 103-111.2001 ; 31 (1) : 56-62.